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Prebiotic investigation of immunoglobulin

Preclinical investigation of bovine-derived protein fractions: bovine plasma, albumin-enriched bovine plasma, and SBI (serum-derived bovine immunoglobulin). The SIFR technology simulates the upper GI tract (mouth, stomach, small intestine), critical given the need for digestion and absorption, and the impact in the colon (gut microbiome).

 

Various bovine plasma fractions were investigated for their prebiotic potential and mechanism of action. To ensure a biorelevant research, the colonic SIFR simulation was preceded by a digestion and absorption step. The immunoglobulin fraction exhibited the most pronounced prebiotic potential. It was used specifically by Bacteroides vulgatus, Lachnoclostridium edouardi and Coprococcus comes, leading to the production of health-promoting SCFA (acetate, propionate & butyrate).

Link to full article: Van den Abbeele et al, 2023, Microorganisms.

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