Decipher
the gut

The gut is a black box where products are being transformed. At Cryptobiotix, we decipher this black box in the lab. We elucidate how ingested actives are affected by digestion and interact with the gut microbiome, impacting overall well-being. With innovative ex vivo and in vitro gut simulations and a dedicated team, we keep pushing the boundaries of preclinical research in the field.

Preclinical data
you can trust

The SIFR technology pipeline simulates the entire gastrointestinal tract: in vitro digestion, ex vivo gut fermentation. This git model is predictive for clinical outcomes.

Products intended to improve gut health frequently fail in clinical trials, due to unreliable data from in vitro models. Cryptobiotix was founded as preclinical CRO to bridge this gap, by developing the ex vivo SIFR® technology pipeline:

  • Uniquely validated to predict clinical outcomes
  • High throughput to investigate many conditions in parallel
  • Advanced data visualisation and interpretation

We understand your
R&D imperatives

swipe

Services

At Cryptobiotix, we have redefined the approach to gut microbiome research. Utilising our innovative SIFR® technology, we offer a solution that combines high throughput and validated predictivity.

This modular technology simulates the entire gastrointestinal tract as needed for your project. If relevant, the upper GI digestion is implemented, before the ex vivo gut fermentation is recreated. By simulating gut conditions ex vivo, we overcome the limitations of traditional in vitro methods, providing actionable insights quickly and cost-effectively.
Our approach enhances biorelevance, increases throughput, and clarifies key findings through advanced data interpretation, fast-tracking and de-risking your product development.

SIFR® technology

Systemic Intestinal Fermentation Research

swipe

SIFR® in screening  mode

In screening mode, swiftly evaluate numerous candidates early in discovery phase and identify the most promising ones. Get quick and targeted insights into the efficacy of your products, dosing, synergies, and many more aspects.

SIFR® in prism mode

In prism mode, characterise the interplay between your products and the gut microbiome to provide unparalleled insights into mechanisms of action, efficacy, and interindividual variations. De-risk your product development with a fully validated and predictive ex vivo simulation, increasing your chances of success at clinical stage and providing you with all the data necessary to support IP and regulatory dossier submissions.

Applications

We simulate the gastrointestinal tract of humans across many ages and physiologies (healthy, diseased) as well as animals. We have extensive experience investigating all types of products in vitro and ex vivo, from pure ingredients to complex matrices.

Gastrointestinal simulation model

Infant digestion and gut microbiome

Infant & toddler

Digestion and gut microbiome for children & adults

Child & adult

Elderly digestion and gut microbiome

Elderly

Digestion and gut microbiome for sick and diseased individuals

Disease & dysbiosis

Feline digestion and gut microbiome

Cat

Canine digestion and gut microbiome

Dog

Poultry digestion and gut microbiome

Poultry

Swine digestion and gut microbiome

Swine

Product types

Fibres & prebiotics

Fibres & prebiotics

Probiotics & LBPs

Probiotics & LBPs

Extracts & postbiotics

Postbiotics & extracts

Drugs and bioactives

Drugs

Whole foods & complex ingredients

Whole foods

Why work with us?

1. De-risk your product development

Predictive insights from the SIFR® de-risk your product development by increasing your chances of clinical success.

2. Gain unprecedented insights in your product

Unravel the mechanism of action of your products and understand how they can contribute to gut health and overall well-being.

3. Shorten time to market

Obtain accurate results and gain critical insights to move forward quickly with IP applications and regulatory dossiers.

Publications

Explore our research findings and insights into the gut microbiome. We’re committed to sharing our discoveries with the scientific community to advance knowledge in this field.

Meet our team

Cryptobiotix is a dynamic company, built around a team of dedicated individuals that share a common vision. Challenging the status quo, empowerment, doing what feels right, and curiosity for the unknown. Since 2021, our team grew to more than 10 employees, passionate about enabling discoveries that can improve lives.

Want to join our team?

De-risk your product
development today

Contact form

We’re always happy to hear from potential customers, partners, and collaborators.

Contact