In a recent SIFR® study serum-derived bovine immunoglobulin (SBI) has shown potential health benefits via gut microbiome modulation. The present study, using again the predictive ex vivo SIFR® technology, expanded upon this observation and explored the health benefits of SBI. Conducted with 24 adults, the study found that SBI significantly enhanced gut barrier integrity and reduced inflammatory markers TNF-α and CXCL10. While the reference prebiotic inulin demonstrated similar effects only on gut barrier integrity, dietary protein was less effective, highlighting the unique benefits of SBI.

The observed impact of SBI on gut barrier integrity and immunity mirrors the results of a clinical trial performed on SBI.

The large sample size (n = 24) allowed for stratification based on microbiome composition. Inulin specifically stimulated Bifidobacteriaceae in subjects with a Bacteroidetes/Firmicutes enterotype, resulting in lower gas production and increased acetate, indicating improved tolerability compared to subjects with a Prevotella enterotype.

Overall, this study underscores the role of the gut microbiome in mediating SBI-induced health benefits, including gut barrier integrity and immunity. Additionally, the SIFR® technology demonstrated its predictive value in stratifying treatment responses, which can aid in designing clinical trials and identifying individuals who may benefit from specific treatments.

Link to full article: Van den Abbeele et al, 2024, Nutrients